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Liu, Mengting; Li, Di; Krčo, Marko; Ho, Luis C.; Xu, Duo; Li, Huixian (, The Astrophysical Journal)
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Liu, Mengting; Ohashi, Masao; Zhou, Qingyang; Sanders, Jacob N.; McCauley, Erin P.; Crews, Phillip; Houk, K. N.; Tang, Yi (, Angewandte Chemie International Edition)Abstract We uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)‐azonazine A from marine‐derivedAspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo‐(l‐Trp‐N‐methyl‐l‐Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole‐substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs.more » « less
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