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Creators/Authors contains: "Liu, Mengting"

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  1. ; ; ; ; ; ; ; ( , Angewandte Chemie International Edition)
    Abstract

    We uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)‐azonazine A from marine‐derivedAspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo‐(l‐Trp‐N‐methyl‐l‐Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole‐substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs.

     
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  2. ; ; ; ; ; ; ; ( , Angewandte Chemie)
    Abstract

    We uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)‐azonazine A from marine‐derivedAspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo‐(l‐Trp‐N‐methyl‐l‐Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole‐substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs.

     
    more » « less
  3. ; ; ; ; ; ; ; ( , Chemical Engineering Journal)
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  4. ; ; ; ; ; ( , The Astrophysical Journal)
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